CHINA·4399js金莎-品牌官网

职称：副教授

邮箱：duzhihong@shzu.edu.cn；1277752137@qq.com（优先推荐）

实验室：科技楼418； 办公室地址：科技楼410

通讯地址：新疆石河子市北四路221号石河子大学4399js金莎官网

个人主页：https://www.x-mol.com/people/duzhihong一、个人简介

杜智宏，男，汉族，中共党员，副教授、硕士研究生导师。主持国家自然科学基金--青年项目1项，兵团重点研发计划项目1项，兵团自然科学计划项目—面上项目1项，石河子大学青年拔尖人才计划项目1项，石河子大学高层次人才科研启动项目1项，入选新疆维吾尔自治区天池英才计划（青年博士）。参与国家社科基金1项，师市科技项目2项。在公开发行的学术刊物上发表本研究领域学术论文30余篇。目前主讲本科生课程《有机化学》、《大学化学B》和《环境化学》，主讲研究生课程《催化化学》。

二、研究方向：

1. 手性有机催化剂及配体的设计与合成；

2. 廉价过渡金属催化的不对称合成

3. 精细化学品的绿色合成技术研发（涵盖乙醛酸及其下游产品、(R)-泛解酸内酯、氨基酸及其衍生物）；

4.手性共价有机框架材料（CCOF）的设计、制备与应用研究。

三、招生专业：0730 化学

每年2-3人，欢迎对有机化学感兴趣的本科生来实验室读研或者交流。

四、教育经历:

2015.09-2021.09  兰州大学    生物化学与分子生物学专业  博士

2011.09-2015.07  长江大学    生命科学学院生物技术专业  学士

五、工作经历:

2025.02—2026.02：  新疆生产建设兵团科学技术局     跟班学习

2023.06— 至今：   石河子大学4399js金莎官网环工系    副教授  硕士研究生导师

2022.09—2023.06：  石河子大学4399js金莎官网环工系    副教授

2021.09—2022.09：  石河子大学4399js金莎官网环工系    讲  师

六、科研项目

1. 兵团重点研发计划项目—攻关项目，2025AB023，2025-2028，180万，主持，在研。

2. 兵团自然科学计划项目—面上项目，2025DA044，2025-2028，30万，主持，在研。

3. 石河子大学科技计划项目—青年拔尖，BJZK20241，2025-2027，10万，主持，在研。

4. 国家自然科学基金-青年基金，非均相肽催化剂的设计合成及其在连续流不对称Aldol反应中的应用，22201186, 2023-2025，30万，结题。

5. 新疆维吾尔自治区天池英才计划—青年博士项目，具有C2-轴对称结构的手性伯胺催化剂的设计合成及应用，2023-2025，60万，结题。

6. 石河子大学高层次人才启动项目，手性棉酚催化剂的设计开发及其在不对称仿生催化甘氨酸α-位官能化反应中的应用，2022ZK005，2022-2025，10万，结题。

七、学术论文及专著：

（一）专著

1. Da, Chao-Shan; Du, Zhi-Hong; Wang, Pei. 3.05 The Aldol Reaction: Organocatalytic Approach. In Comprehensive Organic Synthesis (Third Edition), https://doi.org/10.1016/B978-0-323-96025-0.00127-7, Elsevier, 2025; pp 250-336.

（二）论文

2026年度

[1] Lv，Xiao-Xiong；Wang Wen-Long； Chen，Fei； Bo，Chunbo； Li，Min； Liu，Ning*； Du, Zhi-Hong*.Novel C₂-Symmetric Chiral Bifunctional Primary Amine Catalysts: Design, Synthesis and Application in Asymmetric Aldol Reaction，Chin. J. Chem.2026. 44, 1941-1948. (封面文章，1区Top)

[2] Wang，Zhuo-Yi； Chen，Fei； Bo，Chunbo； Li，Min； Liu，Ning*； Du, Zhi-Hong*. Amine-Catalyzed [3+3] Annulation Reaction Between α-Alkylidene Pyrazolinones and α,β-Unsaturated Aldehydes for the Construction of Spiropyrazolones，Synthesis, 2026. 545-551.

[3]王文龙, 温家旭, 陈飞, 薄春博, 李敏, 刘宁*, 杜智宏*. 铜催化的3-羟基-2-萘甲酸酯的不对称氧化偶联反应：氨基酸类配体的设计与优化. Chin. J. Org. Chem. 2026, 46, 167-180.

2025年度

[1]Wen，Jia-Xu； Chen，Fei； Bo，Chunbo； Li，Min； Liu，Ning*； Du, Zhi-Hong*. Chiral Copper Complex-Catalyzed Enantioselective Oxidative Cross-Coupling of 2 Naphthols for Synthesis of C₁ Symmetric BINOLs，J. Org. Chem. 2025, 90, 17285–17293.

[2] Zhao, Peng-Fei; Wang, Ke; Wen, Jia-Xu; Zhu, Zhang-Mei-Duo; Zhang, Hua; Wang, Zi-Heng; Liao, Yu-Xin; Da, Chao-Shan; Du, Zhi-Hong*. Recent advances in chiral phosphoric acids for asymmetric organocatalysis: a catalyst design perspective. Org. Biomol. Chem.2025, 23 (35), 7872-7913.

[3] Li, Xiao-Bin; Lv, Xiao-Xiong; Chen, Fei; Du, Zhi-Hong*; Bo, Chun-Bo; Li, Min; Wei, Donghui*; Liu, Ning*; Cobalt-Catalyzed Amide Bond Formation from Esters and Amines, J. Org. Chem. 2025, 14871-14880.

[4] Yuan, Meng; Liu, Yang-Xin; Ding, Tie-Ying; Zhang, Ze-Xuan; Lian, Tian-Rui; Zhao, Peng-Fei; Du, Zhi-Hong; Da, Chao-Shan*. Suppression of rapid deactivation of catalytic tetrapeptides in the asymmetric Michael addition of aldehydes to nitroolefins by supporting them on polymers. Org. Biomol. Chem.2025, 23 (28), 6819-6831.

[5] Yuan, Meng; Ding, Tie-Ying; Liu, Yang-Xin; Du, Zhi-Hong; Lian, Tian-Rui; Da, Chao-Shan*. Resin-supported peptide-catalyzed asymmetric aldol reaction of aldehydes for the synthesis of (R)-pantolactone. Org. Biomol. Chem.2025, 23 (25), 6191-6199.

[6] Wu, Di; Wang, Yang; Tao, Sheng; Wang, Tao; Chen, Fei; Du, Zhi-Hong; Bo, Chun‐Bo; Li, Min; Dai, Bin; Wei, Donghui; Liu Ning*. N-Heterocyclic Carbene-Diboron-Substrate Cooperatively Facilitate Direct Amidation of Carboxylic Acids and Amines. Adv. Syn. Catal.2025, 367 (11), e202401441.

[7] Wang, Yao; Du, Zhi-Hong; Bo, Chunbo; Li, Min; Chen, Fei; Liu, Ning*. Synthesis of α,β‐Unsaturated Carbonyl Compounds via Cu/TEMPO/O₂ Aerobic Catalytic System. Chem Eur. J. 2025, 31 (11), e202403950.

[8] Wang, Wen-Long; Lv, Xiao-Xiong; Chen, Fei; Liu, Ning*; Du, Zhi-Hong*. Copper–amine-complex-catalyzed highly selective oxidative cross-coupling of 2-naphthols: Synthesis of C₁-Symmetric BINOLs. Tetrahedron, 2025, 174, 134495.

[9] Wang, Tao; Wu, Di; Chen, Fei; Du, Zhi-Hong; Bo, Chun-Bo; Li, Min; Liu, Ning*. Molecular molybdenum catalyst covalently anchored onto a polystyrene resin for the alkylation of alcohols with ketones. Fuel, 2025, 400, 135679.

[10]Tao, Sheng; Du, Zhi-Hong; Bo, Chun-Bo; Li, Min; Chen, Fei*; Liu, Ning*. Base-free catalytic systems achieved via the design of copper complexes: synthesis of 2-oxazolidinones from propargylic amines and CO₂. New J. Chem. 2025, 49 (37), 16122-16133.

[11] Shen, Yang-Yang; Li, Xiao-Bin; Chen, Fei; Du, Zhi-Hong; Bo, Chun-Bo; Li, Min; Liu, Ning*. Dehydrogenation of Aromatic Alcohols, Aldehydes, and Ketones Catalyzed by Cu(I) Complexes. J. Org. Chem. 2025, 90 (7), 2644-2651.

[12] Li, Mengmeng; Du, Zhi-Hong; Bo, Chunbo; Li, Min; Chen, Fei*; Liu, Ning*. Zn–N₃ complexes for the cycloaddition of epoxides with CO₂ at atmospheric pressure. New J. Chem. 2025, 49 (30), 13125-13135.

2024年度：

[1] Zhou, Yong-Bo; Chen, Fei*; Du, Zhi-Hong; Liu, Bin-Yuan; Liu, Ning*. Iron(III) Complexes with Pyridine Group Coordination and Dissociation Reversible Equilibrium: Cooperative Activation of CO₂ and Epoxides into Cyclic Carbonates. Inorg. Chem.2024, 63 (35), 16491-16506.

[2] Zhang, Nuo; Zhou, Yong-Bo; Chen, Fei; Du, Zhi-Hong; Bo, Chun-Bo; Li, Min; Liu, Ning*. Visible-Light-Driven (NSNO)Nickel complex catalyzed (Z)-Selective semi-hydrogenation of alkynes. Fuel, 2024, 383, 133844.

[3] Shen, Yangyang; Chen, Fei; Du, Zhi-Hong; Zhang, Hao; Liu, Jichang; Liu, Ning*. Cu(I) Complexes Catalyzed the Dehydrogenation of N-Heterocycles. J. Org. Chem.2024, 89 (7), 4530-4537.

[4] Luo, Yu-Hui; Tao, Sheng; Chen, Fei; Du, Zhi-Hong; Zhang, Hao; Li, Min; Liu, Ning*. Boron–pyridine nitrogen cooperative catalytic conversion of carbon dioxide and epoxides to cyclic carbonates. Cata. Sc. Technol.2024, 14 (22), 6692-6700.

2023年度：

[1] Wang, Yu-Bin; Chen, Fei; Li, Min; Bu, Qingqing; Du, Zhi-Hong; Liu, Jichang; Dai, Bin*; Liu, Ning*. Visible-light-promoted synthesis of gem-dihaloenones. Green Chem. 2023, 25 (3), 1191-1200.

[2] Lv, Xiao-Xiong; Liu, Ning*; Chen, Fei; Zhang, Hao; Du, Zhi-Hong*; Wang, Pei; Yuan, Meng; Da, Chao Shan. Highly asymmetric aldol reaction of isatins and ketones catalyzed by chiral bifunctional primary-amine organocatalyst on water. Org. Biomol. Chem.2023, 21 (43), 8695-8701.

[3]Du, Zhi‐Hong*; Lv, Xiao‐Xiong; Liu, Ning; Chen, Fei; Yuan, Meng; Da, Chao‐Shan. Asymmetric Synthesis of Pantolactone: Recent Advances. Eur. J. Org. Chem.2023, 26 (46), e202300918.

[4] Bo, Chunbo; Chen, Fei; Bu, Qingqing; Du, Zhi-Hong; Li, Min; Dai, Bin; Liu, Ning*. Visible-Light-Driven Organocatalytic Alkoxylation of Benzylic C–H Bonds. J. Org. Chem.2023, 88 (6), 3532-3538.

2022年度

[1]Du, Zhi-Hong*; Da, Chao-Shan; Yuan, Meng; Tao, Bao-Xiu; Ding, Tie-Ying. Efficient Catalyst-Free Henry Reaction between Nitroalkanes and Aldehydes or Trifluoromethyl Ketones Promoted by Tap Water. Synthesis, 2022, 54 (24), 5461-5470.

2021年度

[1] Xu, Yan-Li; Qin, Zhou-Zhou; Wang, Yu-Xia; Zhao, Peng-Fei; Li, Hong-Feng; Du, Zhi-Hong; Da, Chao-Shan*. Highly enantioselective one-pot sequential synthesis of valerolactones and pyrazolones bearing all-carbon quaternary stereocentres. Org. Biomol. Chem. 2021, 19 (7), 1610-1615.

[2] Wang, Pei; Zhang, Yang; Yang, Hong; Ma, Guo‐Rong; Wang, Jin‐Bao; Yang, Wen; Du, Zhi-Hong; Da, Chao‐Shan*. Enantioselective Cross‐Aldol Reaction with Ketones and Non‐Enolizable Ketones Catalyzed by Tetrapeptides. ChemistrySelect, 2021, 6 (30), 7722-7726.

[3]Du, Zhi-Hong; Yuan, Meng; Tao, Bao‐Xiu; Qin, Wen‐Juan; Liang, Xiang‐Ming; Li, Yu-Yan; Lin, Hang; Zhang, Lian‐Chun; Da, Chao‐Shan*. Organocatalyzed Highly Enantioselective Aldol Reaction of Aldehydes for Synthesis of (R)‐Pantolactone. Asian J. Org. Chem., 2021, 10 (5), 1167-1172.

2020年度及以前

[1] Han, Zhi-Jian; Zhang, Ze-Xuan; Li, Wei-Ping; Du, Zhi-Hong; Tao, Bao-Xiu; Da, Chao-Shan*; Jiao, Zuo-Yi; Chen, Hao; Li, Yumin*. Ruthenium-Catalyzed Double C(sp2)−H Functionalizations of Fumaramides with Alkynes for the Divergent Synthesis of Pyridones and Naphthyridinediones. ChemCatChem, 2020, 12 (9), 2538-2547.

[2]Du, Zhi-Hong; Tao, Bao-Xiu; Yuan, Meng; Qin, Wen-Juan; Xu, Yan-Li; Wang, Pei; Da, Chao-Shan*. Peptide-Catalyzed Highly Asymmetric Cross-Aldol Reaction of Aldehydes to Biomimetically Synthesize 1,4-Dicarbonyls. Org. Lett. 2020, 22 (11), 4444-4450.

[3]Du, Zhi-Hong; Qin, Wen-Juan; Tao, Bao-Xiu; Yuan, Meng; Da, Chao-Shan*. N-Primary-amine tetrapeptide-catalyzed highly asymmetric Michael addition of aliphatic aldehydes to maleimides. Org. Biomol. Chem. 2020, 18 (35), 6899-6904.

[4] Wang, Pei; Li, Hong-Feng; Zhao, Jia-Zhen; Du, Zhi-Hong; Da, Chao-Shan*. Organocatalytic Enantioselective Cross-Aldol Reaction of o-Hydroxyarylketones and Trifluoromethyl Ketones. Org. Lett. 2017, 19 (10), 2634-2637.

八、发明专利：

[1]杜智宏，吕晓雄，刘宁，陈飞，薄春博，李敏，一种具有C-2轴对称结构的手性伯胺催化剂及其制备方法和应用，申请号：202411973096.X，申请日：2024年12月30日。

[2]达朝山， 杜智宏，陶宝秀，秦文娟，袁梦，白彦兵，林行，张连春，殷杭华，姜伟林，余建新，刘学愚，金文究，一种手性2-羟基-1,4-二羰基化合物和泛解酸内酯的合成方法，申请(专利)号：CN201910352646.9，授权公告日：2023-09-22.

[3]达朝山，杜智宏，陶宝秀，秦文娟，袁梦，白彦兵，林行，张连春，殷杭华，姜伟林，余建新，刘学愚，金文究，一种手性2-羟基-1,4-二羰基化合物和泛解酸内酯的合成方法。国际公布日，2020-11-05，国际公布号，WO. 2020/220651 A1.

[4]Chao-Shan Da, Zhi-Hong Du, Bao-Xiu Tao, Wen-Juan Qin, Meng Yuan, Yanbing Bai, Xing Lin, Lianchun Zhang, Hanghua Yin, Weilin Jiang, Jianxin Yu, Xueyu Liu, Wenjiu Jin, Method for synthesizing chiral 2-hydroxy-1,4-dicarbonyl compound and patlactone, 2022-09-03, EP 3964494 A1.

[5]达朝山，杜智宏，秦文娟，陶宝秀，白彦兵，林行，张连春，殷杭华，余建新，刘学愚，姜伟林，金文究，一种四肽化合物及制备方法和用途，申请(专利)号：CN201811616048.X，授权公告日：2023-07-28。

[6]达朝山，杜智宏，秦文娟，陶宝秀，白彦兵，林行，张连春，殷杭华，姜伟林， 余建新，刘学愚，金文究，一种四肽化合物及制备方法和用途，国际公布日，2020-07-02，国际公布号，WO. 2020/134727 A1.

[7]Chao-Shan Da, Zhi-Hong Du, Wen-Juan Qin, Bao-Xiu Tao, Yanbing Bai, Xing Lin, Lianchun Zhang, Hanghua Yin, Weilin Jiang, Jianxin Yu, Xueyu Liu, Wenjiu Jin, Tetrapeptide compound, preparation method and thereof, 2021-03-11, EP 3904367 A1.

[8]达朝山，杜智宏，秦文娟，李玉彦，梁向明，白彦兵，林行，张连春, 一种不对称催化合成光学活性2-羟基-3,3-二甲基-4-氧代丁酸酯的方法，申请(专利)号：CN201810573131.7，授权公告日：2022-04-08.

（2026年4月更新）